Inhibitory potentials of ivermectin, nafamostat, and camostat on spike protein and some nonstructural proteins of SARS-CoV-2: Virtual screening approach

The search for potent oral drugs either through synthetic routes or by drug repurposing combating the dreaded covid-19 virus is still ongoing. coronavirus spike glycoprotein and several other non-structural proteins play crucial roles in replication transmission of this virus. Recent research have identified ivermectin, nafamostat, camostat as promising inhibitors SARS-CoV-2 target proteins. broad-spectrum inhibitory action on some was studied silico. glycoprotein, nsp3, nsp5, nsp9, nsp10, nsp13, nsp16 were selected study downloaded from protein data bank. Flexible docking procedure implemented Auto Dock Vina module deployed with receptors. Although ivermectin had best viral nafamostat compound activity virus, having highest binding affinity values – 9.4kcal/mol, 7.9 Kcal/mol, 6.1 8.0 8.7 Kcal/mol respectively. This drug, combination could therefore be explored further potential compounds that modified to curb menace pandemic.